ADGRB2 - adhesion G protein-coupled receptor B2 Gene

Homo sapiens

Also known as BAI2

Gene ID: 576 | Gene type: protein coding

About ADGRB2

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,727,117-31,764,340 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues and 42 paralogues. Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues.

Summary

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the Secretin Receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ADGRB2 Products(3)

mRNA	Protein	Name
NM_001294335.2	NP_001281264.1	adhesion G protein-coupled receptor B2 isoform 1 preproprotein
NM_001294336.2	NP_001281265.1	adhesion G protein-coupled receptor B2 isoform 2 preproprotein
NM_001364857.2	NP_001351786.1	adhesion G protein-coupled receptor B2 isoform 3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	28891236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28891236	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	28891236	GOA
involved in calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	28891236	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28891236	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRB2 Protein Structure

TSP_1

GPS

7tm_2

0
300
600
900
1200
1585 a.a.

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor B2

brain-specific angiogenesis inhibitor 2

Related Diseases

Diseases

Alias

Anal Carcinoma In Situ

Carcinoma In Situ Of Anal Canal	Carcinoma In Situ Of Anus
Anal Carcinoma Stage 0	Anal Intraepithelial Neoplasia Grade Iii
Intraepithelial Neoplasia Of Anal Canal, High Grade	Ain - [Anal Intraepithelial Neoplasia] High Grade

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00346	ADGRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADGRB2	VGNC	VGNC:37634
Felis catus	ADGRB2	VGNC	VGNC:69074
Mus musculus	ADGRB2	MGD	MGI:2451244
Bos taurus	ADGRB2	VGNC	VGNC:25659
Rattus norvegicus	ADGRB2	RGD	RGD:1309431
Macaca mulatta	ADGRB2	VGNC	VGNC:69598

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