JCAD - junctional cadherin 5 associated Gene

Homo sapiens

Also known as KIAA1462

Gene ID: 57608 | Gene type: protein coding

About JCAD

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,012,803-30,115,494 (from NCBI)

This gene has 3 transcripts (splice variants) and 124 orthologues. Broad expression in fat (RPKM 28.1), lung (RPKM 20.0) and 17 other tissues.

Summary

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]

JCAD Products(4)

mRNA	Protein	Name
NM_001350001.2	NP_001336930.1	junctional cadherin 5-associated protein isoform 2
NM_001350021.2	NP_001336950.1	junctional cadherin 5-associated protein isoform 2
NM_001350022.2	NP_001336951.1	junctional cadherin 5-associated protein isoform 1
NM_020848.4	NP_065899.1	junctional cadherin 5-associated protein isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	28705794	GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	28705794	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	28705794	GOA
involved in positive regulation of vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	28705794	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	28705794	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	28705794	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	28705794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JCAD Protein Structure

JCAD

0
300
600
900
1200
1359 a.a.

Protein Preferred Names

Protein Names

junctional cadherin 5-associated protein

junctional protein associated with coronary artery disease

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07032	JCAD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	JCAD	VGNC	VGNC:42183
Bos taurus	JCAD	VGNC	VGNC:56189
Mus musculus	JCAD	MGD	MGI:2685174
Felis catus	JCAD	VGNC	VGNC:63003
Rattus norvegicus	JCAD	RGD	RGD:1562037
Macaca mulatta	JCAD	VGNC	VGNC:73937

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