CIP2A - cellular inhibitor of PP2A Gene

Homo sapiens

Also known as p90; NOCIVA; KIAA1524

Gene ID: 57650 | Gene type: protein coding

About CIP2A

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,549,864-108,589,438 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 2 paralogues. Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues.

Summary

Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CIP2A Products(1)

mRNA	Protein	Name
NM_020890.3	NP_065941.2	protein CIP2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17632056	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	28174209	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	17632056	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	35842428	GOA
involved in broken chromosome clustering	IDA IDA: Inferred from direct assay	37165191	GOA
involved in chromosome organization	IDA IDA: Inferred from direct assay	35121901	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in chromosome	IDA IDA: Inferred from direct assay	35121901	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein CIP2A

cancerous inhibitor of PP2A

CIP2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIP2A	Q8TCG1	PPP2R1A	Homo sapiens	P30153	Anti Bait CoIP	17632056

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135699	TD52		≥95.0%	Unkown
HY-N4317	Ethoxysanguinarine	Inducer	99.73%	Unkown
HY-135699A	TD52 dihydrochloride		99.90%	Unkown
HY-139296	PP2A Cancerous-IN-1	Inhibitor	/	Unkown
HY-RS02718	CIP2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIP2A	RGD	RGD:1310335
Canis familiaris	CIP2A	VGNC	VGNC:39277
Felis catus	CIP2A	VGNC	VGNC:60906
Bos taurus	CIP2A	VGNC	VGNC:27369
Macaca mulatta	CIP2A	VGNC	VGNC:71371
Mus musculus	CIP2A	MGD	MGI:2146335

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