USP37 - ubiquitin specific peptidase 37 Gene

Homo sapiens

Gene ID: 57695 | Gene type: protein coding

About USP37

This gene has 11 transcripts (splice variants), 205 orthologues and 71 paralogues. Broad expression in testis (RPKM 8.0), small intestine (RPKM 5.9) and 25 other tissues.

Summary

Enables cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent Deubiquitinase. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP37 Products(1)

mRNA	Protein	Name
NM_020935.3	NP_065986.3	ubiquitin carboxyl-terminal hydrolase 37

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	14715245	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	21596315	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21596315	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21596315	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	21596315	GOA
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	21596315	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	21596315	GOA
involved in protein deubiquitination	IMP IMP: Inferred from mutant phenotype	27296872	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	27296872	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP37 Protein Structure

UCH

UIM

0
200
400
600
800
979 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 37

deubiquitinating enzyme 37

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15548	USP37 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP37	VGNC	VGNC:36726
Macaca mulatta	USP37	VGNC	VGNC:79220
Rattus norvegicus	USP37	RGD	RGD:2319715
Mus musculus	USP37	MGD	MGI:2442483
Canis familiaris	USP37	VGNC	VGNC:48192
Felis catus	USP37	VGNC	VGNC:66883
Others	USP37	NCBI

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