WDFY4 - WDFY family member 4 Gene

Homo sapiens

Also known as C10orf64

Gene ID: 57705 | Gene type: protein coding

About WDFY4

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:48,684,873-48,982,956 (from NCBI)

This gene has 6 transcripts (splice variants), 254 orthologues and 7 paralogues. Biased expression in lymph node (RPKM 13.1), spleen (RPKM 9.3) and 10 other tissues.

Summary

Predicted to be involved in Autophagy. Predicted to act upstream of or within with a positive effect on CD8-positive, alpha-beta T cell activation. Predicted to act upstream of or within antigen processing and presentation and cellular response to virus. Predicted to be located in early endosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

WDFY4 Products(4)

mRNA	Protein	Name
NM_001370153.1	NP_001357082.1	WD repeat- and FYVE domain-containing protein 4 isoform 2
NM_001370154.1	NP_001357083.1	WD repeat- and FYVE domain-containing protein 4 isoform 3
NM_001394531.1	NP_001381460.1	WD repeat- and FYVE domain-containing protein 4 isoform 1
NM_020945.2	NP_065996.1	WD repeat- and FYVE domain-containing protein 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDFY4 Protein Structure

PH_BEACH

Beach

WD40

0
500
1000
1500
2000
2500
3000
3184 a.a.

Protein Preferred Names

Protein Names

WD repeat- and FYVE domain-containing protein 4

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 6, Presynaptic

Familial Infantile Myasthenia	CMS6
Cmsea	Congenital Myasthenic Syndrome 6
Familial Infantile Myasthenia Gravis 2	Fimg2
Myasthenic Syndrome, Congenital, Associated With Episodic Apnea	Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea
Congenital Myasthenic Syndrome Type Ia2, Formerly	Cms1a2, Formerly
Cms Ia2, Formerly	Myasthenia, Familial Infantile, Formerly
Fim, Formerly	Myasthenia Gravis, Familial Infantile, 2, Formerly
Fimg2, Formerly	Cms Ia2
Cms1a2	Congenital Myasthenic Syndrome 6, Presynaptic
Congenital Myasthenic Syndrome Type Ia2	Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea
Fim	Cms1a
Cms-Ea	Cms Ia
Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea	Congenital Myasthenic Syndrome Type 1a
Congenital Myasthenic Syndrome Type Ia	Myasthenic Syndrome, Congenital, Type 6, Presynaptic

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15757	WDFY4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDFY4	MGD	MGI:3584510
Rattus norvegicus	WDFY4	RGD	RGD:1564142
Canis familiaris	WDFY4	VGNC	VGNC:53018
Macaca mulatta	WDFY4	VGNC	VGNC:106120
Felis catus	WDFY4	VGNC	VGNC:109517
Bos taurus	WDFY4	VGNC	VGNC:55999

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