BRINP2 - BMP/retinoic acid inducible neural specific 2 Gene

Homo sapiens

Also known as FAM5B; DBCCR1L2

Gene ID: 57795 | Gene type: protein coding

About BRINP2

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:177,170,958-177,282,422 (from NCBI)

This gene has 3 transcripts (splice variants), 359 orthologues and 2 paralogues. Biased expression in brain (RPKM 11.7), adrenal (RPKM 4.6) and 1 other tissue.

Summary

Predicted to be involved in cellular response to retinoic acid; negative regulation of mitotic cell cycle; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Implicated in oral squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

BRINP2 Products(1)

mRNA	Protein	Name
NM_021165.4	NP_066988.1	BMP/retinoic acid-inducible neural-specific protein 2 precursor

BRINP2 Protein Structure

MACPF

0
200
400
600
783 a.a.

Protein Preferred Names

Protein Names

BMP/retinoic acid-inducible neural-specific protein 2

DBCCR1-like protein 2

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 37

Spinocerebellar Ataxia Type 37	SCA37
Spinocerebellar Ataxia With Altered Vertical Eye Movements

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10927	BRP	Activator	/	Unkown
HY-RS01621	BRINP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BRINP2	RGD	RGD:708419
Canis familiaris	BRINP2	VGNC	VGNC:38528
Bos taurus	BRINP2	VGNC	VGNC:58363
Felis catus	BRINP2	VGNC	VGNC:60175
Macaca mulatta	BRINP2	VGNC	VGNC:70303
Mus musculus	BRINP2	MGD	MGI:2443333

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