G6PC2 - glucose-6-phosphatase catalytic subunit 2 Gene

Homo sapiens

Also known as IGRP

Gene ID: 57818 | Gene type: protein coding

About G6PC2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:168,901,291-168,910,000 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 166 orthologues and 2 paralogues. Biased expression in pancreas (RPKM 3.9), testis (RPKM 0.4) and 1 other tissue.

Summary

This gene encodes an Enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These Enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

G6PC2 Products(2)

mRNA	Protein	Name
NM_001081686.2	NP_001075155.1	glucose-6-phosphatase 2 isoform 2
NM_021176.3	NP_066999.1	glucose-6-phosphatase 2 isoform 1

G6PC2 Protein Structure

PAP2

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

glucose-6-phosphatase 2

G-6-Pase 2

Related Diseases

Diseases

Alias

Heart Defects, Congenital, And Other Congenital Anomalies

Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome	Pancreatic Agenesis And Congenital Heart Defects
HDCA	PACHD
Congenital Pancreatic Hypoplasia With Diabetes Mellitus And Congenital Heart Disease	Yorifuji-Okuno Syndrome
Yorifuji Okuno Syndrome	Pancreatic Hypoplasia, Congenital, With Diabetes Mellitus And Congenital Heart Disease
Congenital Heart Defects And Other Congenital Anomalies	Hereditary Pancreatic Hypoplasia, Diabetes Mellitus And Congenital Heart Disease
Congenital Pancreatic Agenesis With Diabetes Mellitus And Congenital Heart Disease	Heart Disease, Congenital, And Other Congenital Anomalies

Type 1 Diabetes Mellitus 7

Diabetes Mellitus, Insulin-Dependent, 7	Iddm7
Insulin-Dependent Diabetes Mellitus 7	T1D7

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5	Latent Autoimmune Diabetes In Adults
IDDM5	Insulin-Dependent Diabetes Mellitus 5
T1D5	Lada
Type 1.5 Diabetes	Diabetes Mellitus, Insulin-Dependent, Type 5

X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked	Imd74
Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection	Tlr7 Deficiency
X-Linked Immunodeficiency 74,Covid-19-Related

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Glycogen Storage Disease Ia

Von Gierke Disease	Glycogen Storage Disease Type I
Glycogen Storage Disease I	Hepatorenal Form Of Glycogen Storage Disease
Hepatorenal Glycogenosis	Glucose-6-Phosphatase Deficiency
Glycogen Storage Disease, Type I	Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia
GSD1A	Gsd1
Von Gierke'S Disease	Glycogen Storage Disease Type 1a
Glycogen Storage Disease 1a	Glucose-6-Phosphate Transport Defect
Gsd Ia	Deficiency Of Glucose-6-Phosphatase
Glycogenosis Type I	Glucose-6-Phosphatase Deficiency Glycogen Storage Disease
Glycogenosis Type 1	Glucose-6-Phosphate Deficiency
Gsd I	Gsd Type I
G6p Deficiency Type 1a	Gsd Due To G6p Deficiency Type 1a
Gsd Due To G6p Deficiency Type Ia	Gsd Type 1a
Gsdia	Glycogen Storage Disease Due To G6p Deficiency Type Ia
Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a	Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia
Glycogenosis Type Ia	Gsd-Ia
Storage Disease, Glycogen, Type 1a	Glycogen Storage Disease Type Ia

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Permanent Neonatal Diabetes Mellitus

Pndm	Permanent Diabetes Mellitus Of Infancy
Pdmi	Neonatal Diabetes Mellitus, Permanent

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05192	G6PC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	G6PC2	VGNC	VGNC:29179
Felis catus	G6PC2	VGNC	VGNC:62409
Mus musculus	G6PC2	MGD	MGI:1277193
Canis familiaris	G6PC2	VGNC	VGNC:41041
Rattus norvegicus	G6PC2	RGD	RGD:69398
Macaca mulatta	G6PC2	VGNC	VGNC:84884

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