RAP2C - RAP2C, member of RAS oncogene family Gene

Homo sapiens

Gene ID: 57826 | Gene type: protein coding

About RAP2C

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,203,025-132,219,447 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 31.6), bone marrow (RPKM 18.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and Apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

RAP2C Products(3)

mRNA	Protein	Name
NM_001271186.2	NP_001258115.1	ras-related protein Rap-2c isoform 1 precursor
NM_001271187.2	NP_001258116.1	ras-related protein Rap-2c isoform 2
NM_021183.5	NP_067006.3	ras-related protein Rap-2c isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16213650	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	16213650	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23885123	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17447155	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of endothelial intestinal barrier	IGI IGI: Inferred from genetic interaction	23885123	GOA
involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
NOT involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	23885123	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23885123	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17447155	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16213650	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP2C Protein Structure

Ras

0
100
183 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rap-2c

small GTPase RAP2C

RAP2C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAP2C	Q9Y3L5	RAP1GDS1	Homo sapiens	P52306-5	Y2H Array	32296183
Intra	RAP2C	Q9Y3L5	RAP1GDS1	Homo sapiens	P52306-5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11659	RAP2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAP2C	MGD	MGI:1919315
Rattus norvegicus	RAP2C	RGD	RGD:1588562
Canis familiaris	RAP2C	VGNC	VGNC:45345
Felis catus	RAP2C	VGNC	VGNC:64491
Bos taurus	RAP2C	VGNC	VGNC:33721

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