2. Gene
  3. PTPRB - protein tyrosine phosphatase receptor type B Gene

PTPRB - protein tyrosine phosphatase receptor type B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA

Gene ID: 5787 | Gene type: protein coding

About PTPRB

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,515,870-70,637,429 (from NCBI)

This gene has 11 transcripts (splice variants), 266 orthologues, 35 paralogues and is associated with 89 phenotypes. Broad expression in lung (RPKM 16.0), spleen (RPKM 13.5) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

PTPRB Products(5)

mRNA Protein Name
NM_001109754.4 NP_001103224.1 receptor-type tyrosine-protein phosphatase beta isoform a
NM_001206971.3 NP_001193900.1 receptor-type tyrosine-protein phosphatase beta isoform c precursor
NM_001206972.3 NP_001193901.1 receptor-type tyrosine-protein phosphatase beta isoform d precursor
NM_001330204.2 NP_001317133.1 receptor-type tyrosine-protein phosphatase beta isoform e
NM_002837.6 NP_002828.3 receptor-type tyrosine-protein phosphatase beta isoform b precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cadherin binding IPI
IPI: Inferred from physical interaction
28926625 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12840032 GOA
Biological Process GO Annotation Evidence Reference Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
19116766 GOA
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
22869525 GOA
Cellular Component GO Annotation Evidence Reference Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRB Protein Structure

fn3

fn3: Fibronectin type III domain (36 - 100)

fn3

fn3: Fibronectin type III domain (116 - 189)

fn3

fn3: Fibronectin type III domain (292 - 364)

fn3

fn3: Fibronectin type III domain (379 - 454)

fn3

fn3: Fibronectin type III domain (469 - 541)

fn3

fn3: Fibronectin type III domain (556 - 629)

fn3

fn3: Fibronectin type III domain (644 - 720)

fn3

fn3: Fibronectin type III domain (733 - 807)

fn3

fn3: Fibronectin type III domain (821 - 894)

fn3

fn3: Fibronectin type III domain (908 - 982)

fn3

fn3: Fibronectin type III domain (998 - 1072)

fn3

fn3: Fibronectin type III domain (1087 - 1160)

fn3

fn3: Fibronectin type III domain (1176 - 1248)

fn3

fn3: Fibronectin type III domain (1262 - 1342)

fn3

fn3: Fibronectin type III domain (1357 - 1431)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1727 - 1960)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1997 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase beta

VE-PTP

PTPRB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PTPRB P23467 TEK Homo sapiens Q02763
Phosphatase Assay
19167335
Intra
PTPRB P23467 EGFR Homo sapiens P00533
Phosphatase Assay
19167335
Intra
PTPRB P23467 ERBB2 Homo sapiens P04626
Phosphatase Assay
19167335
Intra
PTPRB P23467 MAPK3 Homo sapiens P27361
Phosphatase Assay
19167335
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Generalized Epilepsy With Febrile Seizures Plus, Type 1

GEFSP1

GEFS+1

Generalized Epilepsy With Febrile Seizures Plus 1

Gefs+, Type 1

Generalised Epilepsy With Febrile Seizures Plus 1

Generalised Epilepsy With Febrile Seizures Plus Type 1

Generalized Epilepsy With Febrile Seizures Plus Type 1

Gefs+ Type 1

Epilepsy, Generalized, With Febrile Seizures Plus, Type 1
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Ovarian Angiosarcoma

Hemangiosarcoma Of Ovary
Diabetic Macular Edema
Liver Angiosarcoma

Angiosarcoma Of Liver

Angiosarcoma Of The Liver

Hemangiosarcoma Of The Liver

Primary Angiosarcoma Of Liver

Kupffer Cell Sarcoma Of Liver

Kupffer Cell Sarcoma Of Unspecified Site
Lymphangiosarcoma

Skin Lymphangiosarcoma

Stewart Treves Syndrome

Lymphangiosarcoma Of Stewart And Treves

Malignant Lymphangioendothelioma

Stewart-Treves Syndrome
Kuhnt-Junius Degeneration

Neovascular Age-Related Macular Degeneration

Exudative Senile Macular Degeneration Of Retina

Senile Macular Degeneration, Wet

Wet Senile Macular Retinal Degeneration

Exudative Age-Related Macular Degeneration

Exudative Macular Degeneration
Vascular Cancer

Blood Vessel Tumors

Malignant Vascular Neoplasm

Renal Vein Leiomyosarcoma

Vascular Neoplasms

Blood Vessel Neoplasm

Blood Vessel Tumor

Blood Vessel Tumour Disorder

Haemangiomatous Tumour

Leiomyosarcoma Of The Renal Vein

Malignant Great Vessel Tumor

Malignant Tumor Of Pulmonary Artery

Malignant Tumor Of Pulmonary Vein

Malignant Vascular Tumor

Neoplasm Of Great Vessel

Pulmonary Artery Malignant Neoplasm

Pulmonary Vein Malignant Neoplasm

Vascular Tissue Neoplasm

Vascular Tumors

Blood Vessel Cancer

Neoplasms, Vascular Tissue

Malignant Neoplasm Of Great Vessels
Generalized Epilepsy With Febrile Seizures Plus

Gefs+

Genetic Epilepsy With Febrile Seizures Plus

Generalized Epilepsy With Febrile Seizures-Plus

Genetic Epilepsy With Febrile Seizures-Plus

Epilepsy, Generalized, With Febrile Seizures Plus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11433 PTPRB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPRB MGD MGI:97809
Macaca mulatta PTPRB VGNC VGNC:76611
Bos taurus PTPRB VGNC VGNC:33545
Rattus norvegicus PTPRB RGD RGD:1305922
Felis catus PTPRB VGNC VGNC:69169
Canis familiaris PTPRB VGNC VGNC:45183