2. Gene
  3. PTPRCAP - protein tyrosine phosphatase receptor type C associated protein Gene

PTPRCAP - protein tyrosine phosphatase receptor type C associated protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LPAP; CD45-AP

Gene ID: 5790 | Gene type: protein coding

About PTPRCAP

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,435,510-67,437,682 (from NCBI)

This gene has 1 transcript (splice variant) and 88 orthologues. Biased expression in spleen (RPKM 58.4), lymph node (RPKM 46.1) and 9 other tissues.

Summary

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine Phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

PTPRCAP Products(1)

mRNA Protein Name
NM_005608.3 NP_005599.1 protein tyrosine phosphatase receptor type C-associated protein precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11390434 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein tyrosine phosphatase receptor type C-associated protein

CD45 associated protein

PTPRCAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PTPRCAP Q14761 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
PTPRCAP Q14761 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
PTPRCAP Q14761 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gallbladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Gallbladder

Epidermoid Gallbladder Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11435 PTPRCAP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PTPRCAP VGNC VGNC:76613
Bos taurus PTPRCAP VGNC VGNC:33547
Mus musculus PTPRCAP MGD MGI:97811
Felis catus PTPRCAP VGNC VGNC:104318
Rattus norvegicus PTPRCAP RGD RGD:1559601