PTPRN2 - protein tyrosine phosphatase receptor type N2 Gene

Homo sapiens

Also known as IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2

Gene ID: 5799 | Gene type: protein coding

About PTPRN2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:157,539,056-158,587,823 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 200 orthologues and 35 paralogues. Broad expression in brain (RPKM 7.2), stomach (RPKM 4.9) and 18 other tissues.

Summary

This gene encodes a protein with sequence similarity to receptor-like Protein tyrosine phosphatases. However, tyrosine Phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol Phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of Insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

PTPRN2 Products(5)

mRNA	Protein	Name
NM_001308267.2	NP_001295196.1	receptor-type tyrosine-protein phosphatase N2 isoform 4 precursor
NM_001308268.2	NP_001295197.1	receptor-type tyrosine-protein phosphatase N2 isoform 5
NM_002847.5	NP_002838.2	receptor-type tyrosine-protein phosphatase N2 isoform 1 precursor
NM_130842.4	NP_570857.2	receptor-type tyrosine-protein phosphatase N2 isoform 2 precursor
NM_130843.4	NP_570858.2	receptor-type tyrosine-protein phosphatase N2 isoform 3 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRN2 Protein Structure

RESP18

Receptor_IA-2

Y_phosphatase

0
200
400
600
800
1015 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase N2

IAR/receptor-like protein-tyrosine phosphatase

Related Diseases

Diseases

Alias

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Diabetes Mellitus

Diabetes

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5	Latent Autoimmune Diabetes In Adults
IDDM5	Insulin-Dependent Diabetes Mellitus 5
T1D5	Lada
Type 1.5 Diabetes	Diabetes Mellitus, Insulin-Dependent, Type 5

Bleeding Disorder, Platelet-Type, 17

Platelet-Type Bleeding Disorder 17	BDPLT17
Thrombasthenia-Thrombocytopenia, Hereditary	Hereditary Thrombasthenia-Thrombocytopenia
Autosomal Dominant Macrothrombocytopenia Gfi1b-Related	Autosomal Dominant Platelet Disorder Gfi1b-Related
Bleeding Disorder, Platelet Type 17

Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly

MARCH	Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia And Hydranencephaly
Multinucleated Neurons-Anhydramnios-Renal Dysplasia-Cerebellar Hypoplasia-Hydranencephaly Syndrome	Hydranencephaly With Renal Aplasia-Dysplasia
March Syndrome

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1	Diabetes Mellitus, Insulin-Dependent, 2
IDDM2	Insulin-Dependent Diabetes Mellitus 2
NIDDM1	Diabetes Mellitus, Noninsulin-Dependent 1
T1D2	Type 2 Diabetes Mellitus 1
T2D1	Noninsulin-Dependent Diabetes Mellitus 1
Diabetes Mellitus, Non-Insulin-Dependent, 1	Type 2 Diabetes Mellitus 1, Susceptibility To
Diabetes Mellitus, Insulin-Dependent, Type 2	Diabetes Mellitus, Non-Insulin-Dependent

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11445	PTPRN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPRN2	VGNC	VGNC:45194
Mus musculus	PTPRN2	MGD	MGI:107418
Felis catus	PTPRN2	VGNC	VGNC:80666
Macaca mulatta	PTPRN2	VGNC	VGNC:84752
Bos taurus	PTPRN2	VGNC	VGNC:106884
Rattus norvegicus	PTPRN2	RGD	RGD:61904

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