PTBP2 - polypyrimidine tract binding protein 2 Gene

Homo sapiens

Also known as nPTB; PTBLP; brPTB

Gene ID: 58155 | Gene type: protein coding

About PTBP2

Cytogenetic location: 1p21.3 Genomic coordinates (GRCh38): 1:96,721,784-96,823,739 (from NCBI)

This gene has 19 transcripts (splice variants), 277 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.6), brain (RPKM 9.8) and 24 other tissues.

Summary

The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of Other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

PTBP2 Products(8)

mRNA	Protein	Name
NM_001300985.2	NP_001287914.1	polypyrimidine tract-binding protein 2 isoform 1
NM_001300986.2	NP_001287915.1	polypyrimidine tract-binding protein 2 isoform 2
NM_001300987.2	NP_001287916.1	polypyrimidine tract-binding protein 2 isoform 3
NM_001300988.2	NP_001287917.1	polypyrimidine tract-binding protein 2 isoform 4
NM_001300989.2	NP_001287918.1	polypyrimidine tract-binding protein 2 isoform 5
NM_001300990.2	NP_001287919.1	polypyrimidine tract-binding protein 2 isoform 7
NM_001410833.1	NP_001397762.1	polypyrimidine tract-binding protein 2 isoform 8
NM_021190.4	NP_067013.1	polypyrimidine tract-binding protein 2 isoform 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26871637	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of RNA splicing	IDA IDA: Inferred from direct assay	18335065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTBP2 Protein Structure

RRM_5

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

polypyrimidine tract-binding protein 2

PTB-like protein

PTBP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83157	PTBP2 Antibody (YA2902)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Patellar Tendinitis

Patellar Tendonitis

Adenoiditis

Chronic Adenoiditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11352	PTBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTBP2	MGD	MGI:1860489
Felis catus	PTBP2	VGNC	VGNC:64421
Macaca mulatta	PTBP2	VGNC	VGNC:76280
Bos taurus	PTBP2	VGNC	VGNC:55667
Rattus norvegicus	PTBP2	RGD	RGD:1359267
Canis familiaris	PTBP2	VGNC	VGNC:54061

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