CXCL16 - C-X-C motif chemokine ligand 16 Gene

Homo sapiens

Also known as SRPSOX; CXCLG16; SR-PSOX

Gene ID: 58191 | Gene type: protein coding

About CXCL16

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,733,533-4,739,928 (from NCBI)

This gene has 5 transcripts (splice variants) and 88 orthologues. Broad expression in lung (RPKM 40.7), testis (RPKM 23.8) and 24 other tissues.

Summary

Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to interferon-gamma; and response to tumor necrosis factor. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma. [provided by Alliance of Genome Resources, Apr 2022]

CXCL16 Products(2)

mRNA	Protein	Name
NM_001100812.2	NP_001094282.2	C-X-C motif chemokine 16 isoform 1 precursor
NM_001386809.1	NP_001373738.1	C-X-C motif chemokine 16 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	18373975	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	18373975	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	18373975	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	18373975	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18373975	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-X-C motif chemokine 16

CXC chemokine ligand 16

Recombinant CXCL16 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72961	CXCL16 Protein, Human (HEK293, His)	Q9H2A7 (N30-T205)/NP_071342.2 (N49-T224)	≥95%
HY-P77910	CXCL16 Protein, Human (HEK293, Fc)	Q9H2A7 (N30-T205)	≥95%

Related Diseases

Diseases

Alias

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122197	ML339	Antagonist	99.88%	Unkown
HY-RS03389	CXCL16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXCL16	VGNC	VGNC:71422
Bos taurus	CXCL16	VGNC	VGNC:27851
Mus musculus	CXCL16	MGD	MGI:1932682
Rattus norvegicus	CXCL16	RGD	RGD:1562928
Felis catus	CXCL16	VGNC	VGNC:61298
Canis familiaris	CXCL16	VGNC	VGNC:53326
Others	CXCL16	NCBI

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