2. Gene
  3. Nectin1 - nectin cell adhesion molecule 1 Gene

Nectin1 - nectin cell adhesion molecule 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PRR; HIgR; HveC; PRR1; Cd111; Pvrl1; nectin-1

Gene ID: 58235 | Gene type: protein coding

About Nectin1

Summary

Enables protein homodimerization activity and signaling receptor activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within several processes, including camera-type eye development; desmosome organization; and enamel mineralization. Located in adherens junction; apical junction complex; and cell-cell contact zone. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic active zone membrane. Is expressed in brain; oral region epithelium; sensory organ; skin; and upper jaw molar. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Nectin1 Products(1)

mRNA Protein Name
NM_021424.3 NP_067399.2 nectin-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12826663 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12826663 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
11090177 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
15728677 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18703497 MGI
acts upstream of or within desmosome organization IMP
IMP: Inferred from mutant phenotype
18703497 MGI
acts upstream of or within enamel mineralization IMP
IMP: Inferred from mutant phenotype
18703497 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
acts upstream of or within iron ion transport IMP
IMP: Inferred from mutant phenotype
18703497 MGI
acts upstream of or within lens morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
15728677 MGI
acts upstream of or within protein localization to cell junction IDA
IDA: Inferred from direct assay
22512338 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
15728677 MGI
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
12515806 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
22512338 MGI
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
23533177 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
11827984 MGI
is active in hippocampal mossy fiber to CA3 synapse IEP
IEP: Inferred from expression pattern
11827984 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11827984 MGI
is active in presynaptic active zone membrane IEP
IEP: Inferred from expression pattern
11827984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nectin-1

herpes virus entry mediator C

herpesvirus entry mediator C

nectin-1 alpha

nectin-1 delta

poliovirus receptor-related protein 1

Recombinant Nectin1 Proteins

Cat. No. Product Name Accession Purity
HY-P77468 Nectin-1 Protein, Mouse (HEK293, Fc) Q9JKF6 (Q31-A354) ≥95%
HY-P77469 Nectin-1 Protein, Mouse (HEK293, His) Q9JKF6 (Q31-A354) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09174 NECTIN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nectin1 NCBI NCBI:5818