Nt5e - 5' nucleotidase, ecto Gene

Rattus norvegicus

Also known as Nt5; CD73

Gene ID: 58813 | Gene type: protein coding

About Nt5e

Primary_assembly 8: 89,270,696-89,314,881 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 249 orthologues and is associated with 6 phenotypes. Biased expression in Liver (RPKM 474.8), Kidney (RPKM 312.5) and 9 other tissues.

Summary

Enables 5'-nucleotidase activity and ferrous iron binding activity. Involved in several processes, including nucleobase-containing small molecule metabolic process; positive regulation of lipid biosynthetic process; and response to aluminum ion. Located in cell surface and synaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Apr 2022]

Nt5e Products(1)

mRNA	Protein	Name
NM_021576.2	NP_067587.2	5'-nucleotidase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-nucleotidase activity	IDA IDA: Inferred from direct assay	1770988	RGD
enables ferrous iron binding	IDA IDA: Inferred from direct assay	11935367	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMP catabolic process	IDA IDA: Inferred from direct assay	21414400	RGD
involved in AMP catabolic process	IMP IMP: Inferred from mutant phenotype	30269308	RGD
involved in adenosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	30269308	RGD
involved in adenosine metabolic process	IDA IDA: Inferred from direct assay	12675911	RGD
involved in positive regulation of lipid biosynthetic process	IEP IEP: Inferred from expression pattern	21372807	RGD
involved in response to aluminum ion	IEP IEP: Inferred from expression pattern	17686601	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21627568	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	1770988	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	21414400	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nt5e Protein Structure

MPP_CD73_N

5_nucleotid_C

0
100
200
300
400
500
576 a.a.

Protein Preferred Names

Protein Names

5'-nucleotidase

5'-NT

ecto-5'-nucleotidase

Recombinant Nt5e Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7449	CD73/5'-Nucleotidase Protein, Rat (HEK293, His)	P21588 (W29-K549)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09612	NT5E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09613	Nt5e Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09614	Nt5e Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990771	Uprevstobart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nt5e	NCBI	NCBI:4907
Macaca fascicularis	Nt5e	NCBI	NCBI:102114976
Mus musculus	Nt5e	NCBI	NCBI:23959

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