2. Gene
  3. Nt5e - 5' nucleotidase, ecto Gene

Nt5e - 5' nucleotidase, ecto Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NT; Nt5; eNT; CD73; 5'-NT; 2210401F01Rik

Gene ID: 23959 | Gene type: protein coding

About Nt5e

Chromosome 9: 88,209,250-88,254,145 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 16 phenotypes. Broad expression in bladder adult (RPKM 18.6), lung adult (RPKM 11.8) and 21 other tissues.

Summary

This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric Enzyme that preferentially uses adenosine monophosphate as a substrate to generate free adenosine. Mice lacking the encoded protein exhibit a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow. [provided by RefSeq, Sep 2016]

Nt5e Products(1)

mRNA Protein Name
NM_011851.4 NP_035981.1 5'-nucleotidase preproprotein

Nt5e Protein Structure

MPP_CD73_N

MPP_CD73_N: cd07409 (30 - 311)

5_nucleotid_C

5_nucleotid_C: pfam02872 (340 - 514)

  • 0
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  • 500
  • 576 a.a.
Protein Preferred Names Protein Names

5'-nucleotidase

ecto-5'-nucleotidase

Recombinant Nt5e Proteins

Cat. No. Product Name Accession Purity
HY-P7448 CD73/5'-Nucleotidase Protein, Mouse (HEK293, His) Q61503 (W29-F550) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09612 NT5E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09613 Nt5e Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09614 Nt5e Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990771 Uprevstobart / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nt5e NCBI NCBI:4907
Macaca fascicularis Nt5e NCBI NCBI:102114976
Rattus norvegicus Nt5e NCBI NCBI:58813