Cysltr1 - cysteinyl leukotriene receptor 1 Gene

Mus musculus

Also known as Cyslt1; CysLT1R

Gene ID: 58861 | Gene type: protein coding

About Cysltr1

Chromosome X: 105,617,952-105,647,285 reverse strand.GRCm39:CM001013.3

This gene has 2 transcripts (splice variants), 177 orthologues, 16 paralogues and is associated with 10 phenotypes. Broad expression in placenta adult (RPKM 1.9), bladder adult (RPKM 1.) and 18 other tissues.

Summary

Enables Leukotriene Receptor activity. Acts upstream of or within several processes, including calcium ion transport; chemotaxis; and inflammatory response to antigenic stimulus. Is integral component of plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl Leukotriene Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr1 Products(3)

mRNA	Protein	Name
NM_001281859.1	NP_001268788.1	cysteinyl leukotriene receptor 1 isoform a
NM_001281862.1	NP_001268791.1	cysteinyl leukotriene receptor 1 isoform b
NM_021476.5	NP_067451.2	cysteinyl leukotriene receptor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables leukotriene receptor activity	IDA IDA: Inferred from direct assay	11226226	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19561298	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	16002666	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	11226226	MGI
acts upstream of or within chemotaxis	IDA IDA: Inferred from direct assay	16002666	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	16002666	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	20574000	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11226226	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cysltr1 Protein Structure

7tmA_CysLTR1

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

cysteinyl leukotriene receptor 1

LTD4 receptor

cysteinyl leukotriene D4 receptor

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13315	Montelukast sodium	Antagonist	99.84%	Yes
HY-13315A	Montelukast	Antagonist	99.94%	Yes
HY-13315B	Montelukast dicyclohexylamine	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13315S1	Montelukast-d6 sodium	Antagonist	≥96.0%	Unkown
HY-13315S	Montelukast-d6	Antagonist	/	Unkown
HY-RS03494	CYSLTR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03495	Cysltr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03496	Cysltr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cysltr1	NCBI	NCBI:10800

Name
Email *

	Sorry, but the email address you supplied was invalid.