Casp9 - caspase 9 Gene

Rattus norvegicus

Also known as Mch6; Apaf3; Casp9_v1; Ice-Lap6; Casp-9-CTD

Gene ID: 58918 | Gene type: protein coding

About Casp9

Primary_assembly 5: 154,109,046-154,126,626 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 204 orthologues, 12 paralogues and is associated with 64 phenotypes. Biased expression in Spleen (RPKM 7.4), Adrenal (RPKM 66.9) and 9 other tissues.

Summary

Enables cysteine-type peptidase activity. Involved in several processes, including glial cell apoptotic process; response to estradiol; and response to ischemia. Located in cytosol; mitochondrion; and nucleus. Used to study pre-malignant neoplasm. Biomarker of several diseases, including cerebrovascular disease (multiple); heart disease (multiple); kidney disease (multiple); neurodegenerative disease (multiple); and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (Caspase 9). [provided by Alliance of Genome Resources, Apr 2022]

Casp9 Products(1)

mRNA	Protein	Name
NM_031632.2	NP_113820.1	caspase-9

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	16336964	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18485100	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16987298	RGD
involved in glial cell apoptotic process	IEP IEP: Inferred from expression pattern	18931364	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	27665619	RGD
involved in leukocyte apoptotic process	IEP IEP: Inferred from expression pattern	26861981	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17869439	RGD
involved in protein processing	IDA IDA: Inferred from direct assay	18316105	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	18598848	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18598848	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	24089674	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	11934844	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18289516	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	17297389	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp9 Protein Structure

CARD_CASP9

CASc

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

caspase-9

25 kDa caspase-9 dominant negative protein	Ice-like apoptotic protease 6
apoptotic protease Mch-6	apoptotic protease activating factor 3
caspase 9, apoptosis-related cysteine peptidase	caspase-9 dominant negative form
caspase-9-carboxyl-terminal divergent

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10135	RES-701-1	Antagonist	/	Unkown
HY-P5568	RP 71955	Inhibitor	/	Unkown
HY-RS01969	CASP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01970	Casp9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01971	Casp9 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp9	NCBI	NCBI:842

Name
Email *

	Sorry, but the email address you supplied was invalid.