RES-701-1 

RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ET_B receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET)-1) to the ET_B receptor, with an IC₅₀ value of 10 nM^[1][2].

2043.16

C₁₀₃H₁₁₅N₂₃O₂₃

151308-34-8

Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp (Lactam bridge:Gly1-Asp9)

GNWHGTAPDWFFNYYW (Lactam bridge: Gly1-Asp9)

OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CC=C(C=C4)O)=O)NC([C@H](CC(N)=O)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC6=CC=CC=C6)NC([C@@H](NC([C@H]7NC([C@@]8([H])N(C([C@@H](NC([C@](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(C7)=O)=O)CC(N)=O)=O)CC9=CNC%10=CC=CC=C9%10)=O)CC%11=CN=CN%11)=O)=O)([H])[C@H](O)C)=O)C)=O)CCC8)=O)=O)CC%12=CNC%13=CC=CC=C%12%13)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tanaka T, et al. RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin. Mol Pharmacol. 1994 Apr;45(4):724-30.

  [2]. Yamasaki M, et al. RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701 II. Determination of the primary sequence[J]. The Journal of Antibiotics, 1994, 47(3): 276-280.