Ptafr - platelet-activating factor receptor Gene

Rattus norvegicus

Gene ID: 58949 | Gene type: protein coding

About Ptafr

Primary_assembly 5: 144,765,976-144,795,251 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 223 orthologues, 6 paralogues and is associated with 21 phenotypes. Biased expression in Spleen (RPKM 63.9), Lung (RPKM 25.3) and 9 other tissues.

Summary

Enables mitogen-activated protein kinase binding activity and platelet activating factor receptor activity. Involved in several processes, including positive regulation of gene expression; positive regulation of transport; and regulation of cellular extravasation. Located in plasma membrane. Used to study several diseases, including acute kidney failure; neutropenia; perinatal necrotizing enterocolitis; pleurisy; and transient cerebral ischemia. Biomarker of conjunctivitis; sciatic neuropathy; and transient cerebral ischemia. Orthologous to human PTAFR (platelet activating factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptafr Products(1)

mRNA	Protein	Name
NM_053321.2	NP_445773.1	platelet-activating factor receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mitogen-activated protein kinase binding	IDA IDA: Inferred from direct assay	23911909	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23911909	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9495811	RGD
involved in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	IEP IEP: Inferred from expression pattern	9321918	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	2170386	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	17515866	RGD
involved in cellular response to gravity	IEP IEP: Inferred from expression pattern	15659787	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	3019921	RGD
involved in parturition	IMP IMP: Inferred from mutant phenotype	1849751	RGD
involved in positive regulation of cellular extravasation	IMP IMP: Inferred from mutant phenotype	2829894	RGD
involved in positive regulation of gastro-intestinal system smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10821044	RGD
involved in positive regulation of inositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	8798508	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11779582	RGD
involved in positive regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8592427	RGD
involved in positive regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	10528212	RGD
involved in positive regulation of maternal process involved in parturition	IMP IMP: Inferred from mutant phenotype	1849751	RGD
involved in positive regulation of neutrophil degranulation	IMP IMP: Inferred from mutant phenotype	2829894	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	8216700	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10821044	RGD
involved in positive regulation of transcytosis	IMP IMP: Inferred from mutant phenotype	9664076	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	8216700	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	2545780	RGD
involved in positive regulation of voltage-gated chloride channel activity	IDA IDA: Inferred from direct assay	8168510	RGD
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10482285	RGD
involved in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	IEP IEP: Inferred from expression pattern	9065783	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	10447766	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9065783	RGD
involved in response to organophosphorus	IEP IEP: Inferred from expression pattern	9321918	RGD
involved in response to symbiotic bacterium	IEP IEP: Inferred from expression pattern	10447766	RGD
involved in transcytosis	IMP IMP: Inferred from mutant phenotype	9664076	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

platelet-activating factor receptor

PAF-R

PAFr

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11347	PTAFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11348	Ptafr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11349	Ptafr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptafr	NCBI	NCBI:5724

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