Map2k2 - mitogen activated protein kinase kinase 2 Gene

Rattus norvegicus

Also known as Prkmk2

Gene ID: 58960 | Gene type: protein coding

About Map2k2

Primary_assembly 7: 8,580,905-8,610,243 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 273 orthologues, 8 paralogues and is associated with 25 phenotypes. Biased expression in Kidney (RPKM 39.2), Muscle (RPKM 261.5) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression and protein phosphorylation. Located in cell cortex and cytosol. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2k2 Products(1)

mRNA	Protein	Name
NM_133283.2	NP_579817.1	dual specificity mitogen-activated protein kinase kinase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	7611406	RGD
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	7611406	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16272159	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	28947594	RGD
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9169613	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	7611406	RGD
involved in response to ischemia	IDA IDA: Inferred from direct assay	9169613	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	16272159	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k2 Protein Structure

PKc_MEK

0
100
200
300
401 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 2

ERK activator kinase 2	MAP kinase kinase 2
MAPK/ERK kinase 2	MAPKK 2
MEK 2	MEK2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08036	MAP2K2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08037	Map2k2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08038	Map2k2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k2	NCBI	NCBI:5605

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