IL22RA1 - interleukin 22 receptor subunit alpha 1 Gene

Homo sapiens

Also known as IL22R; CRF2-9; IL22R1

Gene ID: 58985 | Gene type: protein coding

About IL22RA1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,119,771-24,143,140 (from NCBI)

This gene has 1 transcript (splice variant), 231 orthologues and 11 paralogues. Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues.

Summary

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

IL22RA1 Products(1)

mRNA	Protein	Name
NM_021258.4	NP_067081.2	interleukin-22 receptor subunit alpha-1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12513909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL22RA1 Protein Structure

Tissue_fac

0
100
200
300
400
500
574 a.a.

Protein Preferred Names

Protein Names

interleukin-22 receptor subunit alpha-1

IL-22 receptor subunit alpha-1

IL22RA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL22RA1	Q8N6P7	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	IL22RA1	Q8N6P7	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	IL22RA1	Q8N6P7	IL10RB	Homo sapiens	Q08334	ELISA	15120653
Intra	IL22RA1	Q8N6P7	Q9GZX6-PRO_0000015383	Homo sapiens	Q9GZX6-PRO_0000015383	ELISA	15120653
Intra	IL22RA1	Q8N6P7	IL22	Homo sapiens	Q9GZX6	GMS	12513909
Intra	IL22RA1	Q8N6P7	IL22	Homo sapiens	Q9GZX6	X-Ray Diffraction	18675809

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL22RA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77967	IL-22R alpha 1 Protein, Human (HEK293, Fc)	Q8N6P7 (H16-T228)	≥95%

Related Diseases

Diseases

Alias

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06737	IL22RA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990016	Temtokibart	Inhibitor	99.23%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL22RA1	VGNC	VGNC:30144
Canis familiaris	IL22RA1	VGNC	VGNC:41970
Macaca mulatta	IL22RA1	VGNC	VGNC:106386
Felis catus	IL22RA1	VGNC	VGNC:62905
Rattus norvegicus	IL22RA1	RGD	RGD:1559655
Mus musculus	IL22RA1	MGD	MGI:2663588

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