CARD18 - caspase recruitment domain family member 18 Gene

Homo sapiens

Also known as ICEBERG; UNQ5804; pseudo-ICE

Gene ID: 59082 | Gene type: protein coding

About CARD18

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:105,137,714-105,139,769 (from NCBI)

This gene has 5 transcripts (splice variants), 451 orthologues and 16 paralogues. Biased expression in skin (RPKM 6.9) and esophagus (RPKM 0.8).

Summary

Enables CARD domain binding activity and Caspase binding activity. Involved in inhibition of cysteine-type endopeptidase activity; negative regulation of interleukin-1 beta production; and negative regulation of protein binding activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CARD18 Products(1)

mRNA	Protein	Name
NM_021571.4	NP_067546.1	caspase recruitment domain-containing protein 18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11821383	GOA
enables caspase binding	IPI IPI: Inferred from physical interaction	11536016	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11536016	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in inhibition of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	11821383	GOA
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	11536016	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	11536016	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	11536016	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD18 Protein Structure

CARD

0
90 a.a.

Protein Preferred Names

Protein Names

caspase recruitment domain-containing protein 18

ICEBERG caspase-1 inhibitor

Related Diseases

Diseases

Alias

Asbestos-Related Lung Carcinoma

Colon Sarcoma

Colonic Sarcoma

Alveolar Periostitis

Dry Socket	Alveolitis Of Jaw
Dry Tooth Socket	Alveolar Pyorrhea
Alveolar Osteitis	Alveolitis Sicca Dolorosa
Alveolodental Periostitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01919	CARD18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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