RASGRF1 - Ras protein specific guanine nucleotide releasing factor 1 Gene

Homo sapiens

Also known as GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1

Gene ID: 5923 | Gene type: protein coding

About RASGRF1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,959,906-79,090,780 (from NCBI)

This gene has 9 transcripts (splice variants), 249 orthologues and 24 paralogues. Biased expression in brain (RPKM 10.4) and lung (RPKM 4.4).

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from Ras protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

RASGRF1 Products(3)

mRNA	Protein	Name
NM_001145648.3	NP_001139120.1	ras-specific guanine nucleotide-releasing factor 1 isoform 3
NM_002891.6	NP_002882.3	ras-specific guanine nucleotide-releasing factor 1 isoform 1
NM_153815.3	NP_722522.1	ras-specific guanine nucleotide-releasing factor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	27856453	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	27856453	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRF1 Protein Structure

RhoGEF

RasGEF_N

RasGEF

0
200
400
600
800
1000
1200
1273 a.a.

Protein Preferred Names

Protein Names

ras-specific guanine nucleotide-releasing factor 1

CDC25 like

RASGRF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82705	CDC25 Antibody (YA2450)	WB	Rat

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 18

Platelet-Type Bleeding Disorder 18	BDPLT18
Bleeding Disorder Due To Calcium- And Dag-Regulated Guanine Exchange Factor-1 Deficiency	Bleeding Disorder Due To Caldag-Gefi Deficiency
Bleeding Disorder, Platelet Type 18

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Degenerative Myopia

Pathological Myopia	Myopia, Degenerative
Degenerative Progressive High Myopia	Progressive High Myopia
Progressive High Myopia

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Refractive Error

Refractive Errors

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS11691	RASGRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RASGRF1	VGNC	VGNC:45370
Bos taurus	RASGRF1	VGNC	VGNC:33745
Mus musculus	RASGRF1	MGD	MGI:99694
Felis catus	RASGRF1	VGNC	VGNC:69249
Rattus norvegicus	RASGRF1	RGD	RGD:620395

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