RBMS2 - RNA binding motif single stranded interacting protein 2 Gene

Homo sapiens

Also known as SCR3

Gene ID: 5939 | Gene type: protein coding

About RBMS2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,520,405-56,596,193 (from NCBI)

This gene has 9 transcripts (splice variants), 278 orthologues and 24 paralogues. Broad expression in lung (RPKM 17.5), placenta (RPKM 15.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and Apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

RBMS2 Products(4)

mRNA	Protein	Name
NM_001414459.1	NP_001401388.1	RNA-binding motif, single-stranded-interacting protein 2 isoform 2
NM_001414460.1	NP_001401389.1	RNA-binding motif, single-stranded-interacting protein 2 isoform 3
NM_001414461.1	NP_001401390.1	RNA-binding motif, single-stranded-interacting protein 2 isoform 1
NM_002898.4	NP_002889.1	RNA-binding motif, single-stranded-interacting protein 2 isoform 1

RBMS2 Protein Structure

RRM_1

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

RNA-binding motif, single-stranded-interacting protein 2

suppressor of CDC2 with RNA-binding motif 3

Related Diseases

Diseases

Alias

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11761	RBMS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBMS2	VGNC	VGNC:45428
Felis catus	RBMS2	VGNC	VGNC:69269
Mus musculus	RBMS2	MGD	MGI:1861776
Macaca mulatta	RBMS2	VGNC	VGNC:76687
Bos taurus	RBMS2	VGNC	VGNC:33810
Rattus norvegicus	RBMS2	RGD	RGD:1304813

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