RGS1 - regulator of G protein signaling 1 Gene

Homo sapiens

Also known as 1R20; BL34; IER1; IR20; HEL-S-87

Gene ID: 5996 | Gene type: protein coding

About RGS1

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,575,773-192,580,024 (from NCBI)

This gene has 6 transcripts (splice variants), 242 orthologues and 23 paralogues. Broad expression in appendix (RPKM 110.9), lymph node (RPKM 72.3) and 17 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

RGS1 Products(1)

mRNA	Protein	Name
NM_002922.4	NP_002913.3	regulator of G-protein signaling 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	18434541	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10480894	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10480894	GOA
involved in leukotriene signaling pathway	IDA IDA: Inferred from direct assay	10480894	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	10480894	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	10480894	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10480894	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10480894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS1 Protein Structure

RGS

0
100
209 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 1

B-cell activation protein BL34

Related Diseases

Diseases

Alias

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11902	RGS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RGS1	VGNC	VGNC:45519
Bos taurus	RGS1	VGNC	VGNC:33910
Macaca mulatta	RGS1	VGNC	VGNC:76914
Felis catus	RGS1	VGNC	VGNC:107929
Rattus norvegicus	RGS1	RGD	RGD:3561
Mus musculus	RGS1	MGD	MGI:1354694
Others	RGS1	NCBI

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