RGS7 - regulator of G protein signaling 7 Gene

Homo sapiens

Gene ID: 6000 | Gene type: protein coding

About RGS7

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:240,774,742-241,357,230 (from NCBI)

This gene has 55 transcripts (splice variants), 233 orthologues, 23 paralogues and is associated with 85 phenotypes. Biased expression in brain (RPKM 5.9), adrenal (RPKM 1.5) and 2 other tissues.

Summary

Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGS7 Products(20)

mRNA	Protein	Name
NM_001282773.2	NP_001269702.1	regulator of G-protein signaling 7 isoform 2
NM_001282775.2	NP_001269704.1	regulator of G-protein signaling 7 isoform 3
NM_001282778.2	NP_001269707.1	regulator of G-protein signaling 7 isoform 4
NM_001350113.2	NP_001337042.1	regulator of G-protein signaling 7 isoform 5
NM_001350114.2	NP_001337043.1	regulator of G-protein signaling 7 isoform 5
NM_001350115.2	NP_001337044.1	regulator of G-protein signaling 7 isoform 6
NM_001350116.1	NP_001337045.1	regulator of G-protein signaling 7 isoform 6
NM_001364886.1	NP_001351815.1	regulator of G-protein signaling 7 isoform 7
NM_001374806.1	NP_001361735.1	regulator of G-protein signaling 7 isoform 8
NM_001374807.1	NP_001361736.1	regulator of G-protein signaling 7 isoform 9
NM_001374808.1	NP_001361737.1	regulator of G-protein signaling 7 isoform 5
NM_001374809.1	NP_001361738.1	regulator of G-protein signaling 7 isoform 10
NM_001374810.1	NP_001361739.1	regulator of G-protein signaling 7 isoform 11
NM_001374811.1	NP_001361740.1	regulator of G-protein signaling 7 isoform 13
NM_001374812.1	NP_001361741.1	regulator of G-protein signaling 7 isoform 12
NM_001374813.1	NP_001361742.1	regulator of G-protein signaling 7 isoform 14
NM_001374814.1	NP_001361743.1	regulator of G-protein signaling 7 isoform 15
NM_001374815.1	NP_001361744.1	regulator of G-protein signaling 7 isoform 16
NM_001374816.1	NP_001361745.1	regulator of G-protein signaling 7 isoform 17
NM_002924.6	NP_002915.3	regulator of G-protein signaling 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	36996198	GOA
enables G-protein beta-subunit binding	IPI IPI: Inferred from physical interaction	19376773	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10521509	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	31189666	GOA
involved in negative regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	36996198	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	10521509	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	10521509	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	10521509	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS7 Protein Structure

DEP

G-gamma

RGS

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 7

regulator of G-protein signaling RGS7

Related Diseases

Diseases

Alias

Night Blindness, Congenital Stationary, Type 1b

Congenital Stationary Night Blindness 1b	CSNB1B
Night Blindness, Congenital Stationary, Complete, Autosomal Recessive	Csnb, Complete, Autosomal Recessive
Night Blindness, Congenital Stationary , 1b, Autosomal Recessive	Autosomal Recessive Complete Congenital Stationary Night Blindness
Congenital Stationary Night Blindness 1b Autosomal Recessive	Night Blindness, Congenital Stationary, 1b
Complete Autosomal Recessive Csnb	Complete Congenital Stationary Night Blindness Autosomal Recessive
Blindness, Night, Stationary, Congenital, Type 1b

Prolonged Electroretinal Response Suppression

Bradyopsia

PERRS

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11925	RGS7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RGS7	MGD	MGI:1346089
Bos taurus	RGS7	VGNC	VGNC:33923
Canis familiaris	RGS7	VGNC	VGNC:45536
Macaca mulatta	RGS7	VGNC	VGNC:76692
Rattus norvegicus	RGS7	RGD	RGD:3570
Felis catus	RGS7	VGNC	VGNC:64598

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