FAM3A - FAM3 metabolism regulating signaling molecule A Gene

Homo sapiens

Also known as DLD; 2.19; XAP-7; DXS560S

Gene ID: 60343 | Gene type: protein coding

About FAM3A

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,506,171-154,516,232 (from NCBI)

This gene has 22 transcripts (splice variants), 185 orthologues and 3 paralogues. Ubiquitous expression in small intestine (RPKM 12.0), fat (RPKM 11.4) and 25 other tissues.

Summary

This gene encodes a cytokine-like protein. The expression of this gene may be regulated by Peroxisome Proliferator-activated Receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FAM3A Products(7)

mRNA	Protein	Name
NM_001171132.3	NP_001164603.1	protein FAM3A isoform 1 precursor
NM_001171133.3	NP_001164604.1	protein FAM3A isoform 2
NM_001171134.3	NP_001164605.1	protein FAM3A isoform 3
NM_001282311.2	NP_001269240.1	protein FAM3A isoform 4
NM_001282312.2	NP_001269241.1	protein FAM3A isoform 1 precursor
NM_001363822.2	NP_001350751.1	protein FAM3A isoform 5
NM_021806.4	NP_068578.2	protein FAM3A isoform 1 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	18212107	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	18212107	GOA
involved in negative regulation of antifungal innate immune response	IDA IDA: Inferred from direct assay	18212107	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein FAM3A

cytokine-like protein 2-19

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Ritscher-Schinzel Syndrome 2

RTSC2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04711	FAM3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FAM3A	RGD	RGD:1562076
Mus musculus	FAM3A	MGD	MGI:1913544
Macaca mulatta	FAM3A	VGNC	VGNC:72270
Bos taurus	FAM3A	VGNC	VGNC:28809
Canis familiaris	FAM3A	VGNC	VGNC:54141

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