Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Rattus norvegicus

Also known as Fxr

Gene ID: 60351 | Gene type: protein coding

About Nr1h4

Primary_assembly 7: 23,846,122-23,942,047 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 265.5) and Kidney (RPKM 198.2).

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid receptor activity; and chenodeoxycholic acid binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including lipid homeostasis; liver development; and negative regulation of biosynthetic process. Located in nucleus. Part of receptor complex. Used to study extrahepatic cholestasis; intrahepatic cholestasis; and portal hypertension. Biomarker of bile duct disease (multiple); liver disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; and premature menopause. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 Products(1)

mRNA	Protein	Name
NM_021745.1	NP_068513.1	bile acid receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11533040	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11533040	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11533040	RGD
enables bile acid binding	IDA IDA: Inferred from direct assay	12718893	RGD
enables bile acid binding	IPI IPI: Inferred from physical interaction	12718893	RGD
enables bile acid nuclear receptor activity	IDA IDA: Inferred from direct assay	10334992	RGD
enables chenodeoxycholic acid binding	IDA IDA: Inferred from direct assay	10334992	RGD
contributes to double-stranded DNA binding	IDA IDA: Inferred from direct assay	15047603	RGD
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	10334992	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	12718893	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11533040	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid and bile salt transport	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in bile acid metabolic process	IDA IDA: Inferred from direct assay	12754200	RGD
involved in bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	27993716	RGD
involved in cellular response to bile acid	IDA IDA: Inferred from direct assay	10334992	RGD
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	29235094	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	19136377	RGD
involved in cholesterol homeostasis	IEP IEP: Inferred from expression pattern	23117815	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	11984532	RGD
involved in leukocyte migration involved in inflammatory response	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	15980055	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15860571	RGD
involved in negative regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	29148806	RGD
involved in nuclear receptor-mediated bile acid signaling pathway	IDA IDA: Inferred from direct assay	10334992	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27993716	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11533040	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17065154	RGD
involved in regulation of carbohydrate metabolic process	IMP IMP: Inferred from mutant phenotype	15564327	RGD
involved in regulation of lipid storage	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10334992	RGD
involved in response to cholesterol	IEP IEP: Inferred from expression pattern	25263431	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	15047603	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	12492453	RGD
involved in response to norepinephrine	IMP IMP: Inferred from mutant phenotype	19418582	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	23117815	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	29091898	RGD
involved in triglyceride homeostasis	IDA IDA: Inferred from direct assay	19136377	RGD
involved in triglyceride homeostasis	IEP IEP: Inferred from expression pattern	23117815	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	10334992	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr1h4 Protein Structure

NR_DBD_FXR

NR_LBD_Fxr

0
100
200
300
400
516 a.a.

Protein Preferred Names

Protein Names

bile acid receptor

RXR-interacting protein 14	farnesoid X-activated receptor
farnesol receptor HRR-1	retinoid X receptor-interacting protein 14

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125996	NR1H4 activator 1	Agonist	/	Unkown
HY-RS09531	NR1H4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09532	Nr1h4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09533	Nr1h4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr1h4	NCBI	NCBI:9971

Name
Email *

	Sorry, but the email address you supplied was invalid.