TGIF2 - TGFB induced factor homeobox 2 Gene

Homo sapiens

Gene ID: 60436 | Gene type: protein coding

About TGIF2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,573,464-36,593,950 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 12 paralogues. Ubiquitous expression in endometrium (RPKM 10.3), lymph node (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]

TGIF2 Products(4)

mRNA	Protein	Name
NM_001199513.2	NP_001186442.1	homeobox protein TGIF2
NM_001199514.2	NP_001186443.1	homeobox protein TGIF2
NM_001199515.2	NP_001186444.1	homeobox protein TGIF2
NM_021809.7	NP_068581.1	homeobox protein TGIF2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22783022	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGIF2 Protein Structure

Homeobox_KN

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

homeobox protein TGIF2

5'-TG-3' interacting factor 2

Related Diseases

Diseases

Alias

Holoprosencephaly 4

HPE4	Holoprosencephaly-4
Holoprosencephaly, Type 4

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14456	TGIF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14457	TGIF2LX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TGIF2	VGNC	VGNC:35808
Mus musculus	TGIF2	MGD	MGI:1915299
Rattus norvegicus	TGIF2	RGD	RGD:1560115
Felis catus	TGIF2	VGNC	VGNC:66140
Canis familiaris	TGIF2	VGNC	VGNC:47314

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