2. Gene
  3. Acaca - acetyl-CoA carboxylase alpha Gene

Acaca - acetyl-CoA carboxylase alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ACC1; Acac

Gene ID: 60581 | Gene type: protein coding

About Acaca

Primary_assembly 10: 69,014,170-69,276,457 forward strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 205 orthologues, 4 paralogues and is associated with 12 phenotypes. Biased expression in Adrenal (RPKM 596.3), Thymus (RPKM 517.4) and 9 other tissues.

Summary

Enables Acetyl-CoA Carboxylase activity; biotin binding activity; and kinase binding activity. Involved in fatty acid biosynthetic process; response to organic cyclic compound; and response to xenobiotic stimulus. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Used to study fatty liver disease. Orthologous to human ACACA (Acetyl-CoA Carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Acaca Products(1)

mRNA Protein Name
NM_022193.2 NP_071529.2 acetyl-CoA carboxylase 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables acetyl-CoA carboxylase activity IDA
IDA: Inferred from direct assay
11735100 RGD
enables biotin binding IDA
IDA: Inferred from direct assay
12949377 RGD
Biological Process GO Annotation Evidence Reference Source
involved in fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
11735100 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25943649 RGD
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
12842871 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16979414 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acaca Protein Structure

AccC

AccC: COG0439 (155 - 657)

AccB

AccB: cl33922 (708 - 855)

Biotin_lipoyl

Biotin_lipoyl: pfam00364 (790 - 855)

ACC_central

ACC_central: pfam08326 (857 - 1606)

Carboxyl_trans

Carboxyl_trans: pfam01039 (1706 - 2254)

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  • 2384 a.a.
Protein Preferred Names Protein Names

acetyl-CoA carboxylase 1

ACC-alpha

acetyl-coenzyme A carboxylase alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00119 ACACA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00120 Acaca Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00121 Acaca Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acaca NCBI NCBI:31
Macaca fascicularis Acaca NCBI NCBI:102138812
Macaca mulatta Acaca NCBI NCBI:714218