Grm8 - glutamate metabotropic receptor 8 Gene

Rattus norvegicus

Also known as Glur8; mGlur; Gprc1h; Mglur8; mGluR8b

Gene ID: 60590 | Gene type: protein coding

About Grm8

Primary_assembly 4: 55,805,955-56,730,831 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 288 orthologues, 7 paralogues and is associated with 16 phenotypes. Biased expression in Brain (RPKM 78.5) and Muscle (RPKM 6.3).

Summary

Enables group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in neuron projection; neuronal cell body; and presynaptic membrane. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Used to study Parkinsonism; epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Grm8 Products(1)

mRNA	Protein	Name
NM_022202.1	NP_071538.1	metabotropic glutamate receptor 8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables group III metabotropic glutamate receptor activity	IDA IDA: Inferred from direct assay	9875342	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IDA IDA: Inferred from direct assay	15275822	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IDA IDA: Inferred from direct assay	18533199	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	15275822	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15275822	RGD
involved in regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	16084932	RGD
involved in synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	15275822	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	15275822	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	9295396	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	15275822	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9295396	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12443992	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16045496	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	9295396	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	15275822	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm8 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tmC_mGluR8

0
200
400
600
800
908 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 8

G protein-coupled receptor, family C, group 1, member H	glutamate receptor, metabotropic 8
metabotropic glutamate receptor subtype 8b

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05840	GRM8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05841	Grm8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05842	Grm8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm8	NCBI	NCBI:2918

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