SMAP1 - small ArfGAP 1 Gene

Homo sapiens

Also known as SMAP-1

Gene ID: 60682 | Gene type: protein coding

About SMAP1

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:70,667,883-70,862,015 (from NCBI)

This gene has 6 transcripts (splice variants), 252 orthologues and 28 paralogues. Ubiquitous expression in brain (RPKM 17.8), esophagus (RPKM 10.4) and 25 other tissues.

Summary

The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SMAP1 Products(4)

mRNA	Protein	Name
NM_001044305.3	NP_001037770.1	stromal membrane-associated protein 1 isoform A
NM_001281439.2	NP_001268368.1	stromal membrane-associated protein 1 isoform C
NM_001281440.1	NP_001268369.1	stromal membrane-associated protein 1 isoform D
NM_021940.5	NP_068759.2	stromal membrane-associated protein 1 isoform B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMAP1 Protein Structure

ArfGap

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

stromal membrane-associated protein 1

stromal membrane-associated GTPase-activating protein 1

Related Diseases

Diseases

Alias

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13401	SMAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SMAP1	MGD	MGI:2138261
Rattus norvegicus	SMAP1	RGD	RGD:1585595
Bos taurus	SMAP1	VGNC	VGNC:34983
Canis familiaris	SMAP1	VGNC	VGNC:46527
Felis catus	SMAP1	VGNC	VGNC:102520

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