RPL17 - ribosomal protein L17 Gene

Homo sapiens

Also known as L17; PD-1; RPL23

Gene ID: 6139 | Gene type: protein coding

About RPL17

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:49,488,481-49,492,465 (from NCBI)

This gene has 24 transcripts (splice variants) and 89 orthologues. Ubiquitous expression in ovary (RPKM 688.1), bone marrow (RPKM 341.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

RPL17 Products(16)

mRNA	Protein	Name
NM_000985.5	NP_000976.1	60S ribosomal protein L17 isoform a
NM_001035006.5	NP_001030178.1	60S ribosomal protein L17 isoform a
NM_001199340.2	NP_001186269.1	60S ribosomal protein L17 isoform a
NM_001199341.3	NP_001186270.1	60S ribosomal protein L17 isoform a
NM_001199342.3	NP_001186271.1	60S ribosomal protein L17 isoform a
NM_001199343.3	NP_001186272.1	60S ribosomal protein L17 isoform a
NM_001199344.3	NP_001186273.1	60S ribosomal protein L17 isoform a
NM_001199345.2	NP_001186274.1	60S ribosomal protein L17 isoform b
NM_001369555.1	NP_001356484.1	60S ribosomal protein L17 isoform c
NM_001369556.1	NP_001356485.1	60S ribosomal protein L17 isoform a
NM_001369557.1	NP_001356486.1	60S ribosomal protein L17 isoform a
NM_001369558.1	NP_001356487.1	60S ribosomal protein L17 isoform a
NM_001369560.1	NP_001356489.1	60S ribosomal protein L17 isoform d
NM_001369561.1	NP_001356490.1	60S ribosomal protein L17 isoform d
NM_001369562.1	NP_001356491.1	60S ribosomal protein L17 isoform b
NM_001369563.1	NP_001356492.1	60S ribosomal protein L17 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL17 Protein Structure

Ribosomal_L22

0
100
184 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L17

60S ribosomal protein L23

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12168	RPL17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL17	RGD	RGD:1303019
Mus musculus	RPL17	MGD	MGI:2448270

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