RPS6KB2 - ribosomal protein S6 kinase B2 Gene

Homo sapiens

Also known as KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta

Gene ID: 6199 | Gene type: protein coding

About RPS6KB2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,428,494-67,435,401 (from NCBI)

This gene has 12 transcripts (splice variants), 199 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 31.3), esophagus (RPKM 20.5) and 25 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

RPS6KB2 Products(5)

mRNA	Protein	Name
XM_006718656.4	XP_006718719.1	ribosomal protein S6 kinase beta-2 isoform X2
XM_047427395.1	XP_047283351.1	ribosomal protein S6 kinase beta-2 isoform X1
NM_003952.3	NP_003943.2	ribosomal protein S6 kinase beta-2
XM_047427396.1	XP_047283352.1	ribosomal protein S6 kinase beta-2 isoform X3
NM_001007071.1

RPS6KB2 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

ribosomal protein S6 kinase beta-2

70 kDa ribosomal protein S6 kinase 2	P70S6K2
S6 kinase-related kinase	S6K-beta
S6K-beta-2	p70 S6 kinase beta
p70 S6K-beta	p70 S6KB
p70 ribosomal S6 kinase beta	p70-S6K 2
ribosomal protein S6 kinase, 70kDa, polypeptide 2	serine/threonine-protein kinase 14 beta
serine/threonine-protein kinase 14B

Related Diseases

Diseases

Alias

Coffin-Lowry Syndrome

CLS	Mental Retardation With Osteocartilaginous Abnormalities
Coffin Syndrome 1	Coffin Syndrome
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Coffin Lowry Syndrome

Spotted Fever

Spotted Fevers	Spotted Fever Group Rickettsial Disease
Tick-Borne Rickettsioses	Tick-Borne Typhus Nos
Rocky Mountain Spotted Fever	Sao Paulo Fever
Sao Paulo Typhus	Lone Star Spotted Fever
Colombian Spotted Fever	American Spotted Fever
Tick Typhus Due To Rickettsia Rickettsii	Rocky Mountain Tick Fever
Boutonneuse Fever	Mediterranean Tick Fever
Fièvre Boutonneuse	Mediterranean Spotted Fever
Tick Typhus Due To Rickettsia Conorii	African Tick Typhus
Indian Tick Typhus	Kenya Tick Typhus
North Asian Tick Fever	Siberian Tick Typhus
Tick Typhus Due To Rickettsia Siberica	North Asian Spotted Fever
Queensland Tick Typhus	Queensland Fever

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12265	RPS6KB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12266	Rps6kb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12267	Rps6kb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RPS6KB2	VGNC	VGNC:76934
Canis familiaris	RPS6KB2	VGNC	VGNC:45745
Bos taurus	RPS6KB2	VGNC	VGNC:34147
Mus musculus	RPS6KB2	MGD	MGI:1927343
Rattus norvegicus	RPS6KB2	RGD	RGD:1305144
Felis catus	RPS6KB2	VGNC	VGNC:64760
Others	RPS6KB2	NCBI

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