RPS28 - ribosomal protein S28 Gene

Homo sapiens

Also known as S28; eS28; DBA15

Gene ID: 6234 | Gene type: protein coding

About RPS28

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,321,496-8,323,340 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 563.4), spleen (RPKM 434.5) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS28 Products(1)

mRNA	Protein	Name
NM_001031.5	NP_001022.1	40S ribosomal protein S28

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	24942156	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
located in ribosome	IDA IDA: Inferred from direct assay	25957688	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS28 Protein Structure

Ribosomal_S28e

0
69 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S28

small ribosomal subunit protein eS28

RPS28 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS28	P62857	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	RPS28	P62857	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	RPS28	P62857	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	RPS28	P62857	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Array	25416956
Intra	RPS28	P62857	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Prey Pooling	25416956
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	RPS28	P62857	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	RPS28	P62857	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	RPS28	P62857	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956
Intra	RPS28	P62857	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	RPS28	P62857	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	RPS28	P62857	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis

DBA15	Diamond Blackfan Anemia 15 With Mandibulofacial Dysostosis
Diamond-Blackfan Anemia 15, With Mandibulofacial Dysostosis	Diamond-Blackfan Anemia With Microtia And Cleft Palate
Anemia, Diamond Blackfan, Type 15 With Mandibulofacial Dysostosis

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Diamond-Blackfan Anemia 10

DBA10	Rps26-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 10

Chromosome 5q Deletion Syndrome

5q- Syndrome	Mar
Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality	Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic
5q Deletion Syndrome	5q Minus Syndrome
Refractory Macrocytic Anemia Due To 5q Deletion	Myelodysplastic Syndrome With Isolated Del
Macrocytic Anemia, Refractory, Due To 5q Deletion	5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion
5q Syndrome	Chromosome 5q Deletion
Myelodysplastic Syndrome With 5q Deletion	Myelodysplastic Syndrome With 5q Deletion Syndrome
Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic	5q-Syndrome
Chromosome 5, Trisomy 5q	Loss Of Chromosome 5q
5 Q- Syndrome

Erythrasma

Infection Due To Corynebacterium Minutissimum

Dysostosis

Dysostoses

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12240	RPS28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPS28	VGNC	VGNC:80709
Mus musculus	RPS28	MGD	MGI:1859516
Rattus norvegicus	RPS28	RGD	RGD:621046
Bos taurus	RPS28	VGNC	VGNC:34136
Canis familiaris	RPS28	VGNC	VGNC:108256

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