S100A11 - S100 calcium binding protein A11 Gene

Homo sapiens

Also known as MLN70; S100C; HEL-S-43

Gene ID: 6282 | Gene type: protein coding

About S100A11

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,032,506-152,037,004 (from NCBI)

This gene has 2 transcripts (splice variants), 293 orthologues and 21 paralogues. Broad expression in esophagus (RPKM 707.5), placenta (RPKM 273.6) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]

S100A11 Products(1)

mRNA	Protein	Name
NM_005620.2	NP_005611.1	protein S100-A11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S100 protein binding	IPI IPI: Inferred from physical interaction	10913138	GOA
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	10913138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10913138	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10913138	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21139050	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10913138	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10913138	GOA
located in ruffle	IDA IDA: Inferred from direct assay	10913138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A11 Protein Structure

S_100

EF-hand_1

0
105 a.a.

Protein Preferred Names

Protein Names

protein S100-A11

MLN 70

S100A11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S100A11	P31949	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A11	P31949	TNF	Homo sapiens	P01375	Crosslink	36555597
Intra	S100A11	P31949	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100A11	P31949	S100B	Homo sapiens	P04271	Y2H	10913138
Intra	S100A11	P31949	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72482	S100A11 Protein, Human	P31949 (M1-T105)	≥95%

Related Diseases

Diseases

Alias

Trachea Leiomyoma

Tracheal Neoplasms	Leiomyoma Of The Trachea
Tracheal Neoplasm	Tracheal Leiomyoma

Clear Cell Sarcoma

Sarcoma, Clear Cell	Adult Soft Part Clear Cell Sarcoma
Clear Cell Sarcoma Of Soft Parts	Malignant Melanoma Of Soft Parts
Malignant Melanoma Of Soft Tissues	Melanoma, Malignant, Of Soft Parts
Sarcoma Clear Cell

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12373	S100A11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	S100A11	VGNC	VGNC:54355
Rattus norvegicus	S100A11	RGD	RGD:1303295
Mus musculus	S100A11	MGD	MGI:1338798
Bos taurus	S100A11	VGNC	VGNC:34238
Others	S100A11	NCBI

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