CELA2A - chymotrypsin like elastase 2A Gene

Homo sapiens

Also known as PE-1; AOMS4; ELA2A

Gene ID: 63036 | Gene type: protein coding

About CELA2A

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:15,456,732-15,472,091 (from NCBI)

This gene has 3 transcripts (splice variants), 289 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward pancreas (RPKM 18580.0).

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, Elastase 2A is secreted from the pancreas as a zymogen. In Other species, Elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

CELA2A Products(1)

mRNA	Protein	Name
NM_033440.3	NP_254275.1	chymotrypsin-like elastase family member 2A preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	31358993	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31358993	GOA
enables serine hydrolase activity	IDA IDA: Inferred from direct assay	20179351	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in insulin catabolic process	IDA IDA: Inferred from direct assay	31358993	GOA
involved in regulation of insulin secretion	IDA IDA: Inferred from direct assay	31358993	GOA
involved in regulation of platelet aggregation	IDA IDA: Inferred from direct assay	31358993	GOA
involved in response to insulin	IDA IDA: Inferred from direct assay	31358993	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	31358993	GOA
located in keratohyalin granule	IDA IDA: Inferred from direct assay	20179351	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELA2A Protein Structure

Trypsin

0
100
200
269 a.a.

Protein Preferred Names

Protein Names

chymotrypsin-like elastase family member 2A

chymotrypsin like elastase family member 2A

Recombinant CELA2A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72135	CELA2A Protein, Human (His)	P08217 (V29-N269)	≥95%

Related Diseases

Diseases

Alias

Abdominal Obesity-Metabolic Syndrome 4

AOMS4

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Hypertriglyceridemia 1

Hypertriglyceridemia	Hypertriglyceridemia, Familial
Hypertriglyceridemia, Susceptibility To	HYTG1
FHTR	Hypertriglyceridemias Familial

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Diabetes Mellitus

Diabetes

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10	IDDM10
Insulin-Dependent Diabetes Mellitus 10	Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10
T1D10	Diabetes, Mellitus, Insulin-Dependent 10
Diabetes Mellitus, Insulin-Dependent, Type 10

Celery Allergy

Type 1 Diabetes Mellitus 11

Diabetes Mellitus, Insulin-Dependent, 11	Iddm11
Insulin-Dependent Diabetes Mellitus 11	T1D11
Insulin-Dependent Diabetes Mellitus-11

Netherton Syndrome

NETH	Ns
Netherton Disease	Comel-Netherton Syndrome
Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige	Bamboo Hair Syndrome
Ichthyosis Linearis Circumflexa	Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige
Ilc	Nts
N Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02456	CELA2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CELA2A	MGD	MGI:95316
Rattus norvegicus	CELA2A	RGD	RGD:2548
Others	CELA2A	NCBI

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