CELA2A Protein, Human (His)

The function of the CELA2A protein as elastase goes beyond its traditional role as it not only enhances insulin signaling but also appears to play a potential physiological role in cellular glucose metabolism. This multifaceted protein circulates in the plasma and exerts regulatory effects by reducing platelet overactivation. CELA2A Protein, Human (His) is the recombinant human-derived CELA2A protein, expressed by E. coli , with N-6*His labeled tag. The total length of CELA2A Protein, Human (His) is 241 a.a., with molecular weight of ~29.9 kDa.

CELA2A, identified as an elastase, possesses a distinctive role in cellular glucose metabolism and insulin signaling. This protein is known to circulate in plasma, where it plays a pivotal role in modulating platelet hyperactivation. CELA2A exhibits a dual impact on insulin dynamics, acting to both trigger insulin secretion and facilitate its degradation. Notably, the elastase enhances insulin sensitivity, emphasizing its potential physiological significance in glucose homeostasis. The multifaceted actions of CELA2A highlight its intricate involvement in the regulation of insulin signaling, platelet function, and cellular glucose metabolism.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

P08217 (V29-N269)

63036  [NCBI]

VVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN

Approximately 29.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.