CXCL5 - C-X-C motif chemokine ligand 5 Gene

Homo sapiens

Also known as SCYB5; ENA-78

Gene ID: 6374 | Gene type: protein coding

About CXCL5

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,995,642-73,998,677 (from NCBI)

This gene has 1 transcript (splice variant), 32 orthologues and 12 paralogues. Biased expression in appendix (RPKM 23.4), urinary bladder (RPKM 8.7) and 5 other tissues.

Summary

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in Cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

CXCL5 Products(1)

mRNA	Protein	Name
NM_002994.5	NP_002985.1	C-X-C motif chemokine 5 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	24695525	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL5 Protein Structure

IL8

0
100
114 a.a.

Protein Preferred Names

Protein Names

C-X-C motif chemokine 5

chemokine (C-X-C motif) ligand 5

CXCL5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CXCL5	P42830	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CXCL5	P42830	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CXCL5	P42830	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CXCL5	P42830	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7157	ENA-78/CXCL5 Protein, Human (HEK293)	P42830 (A37-N114)	≥95%
HY-P7158	ENA-78/CXCL5 Protein, Human	P42830 (R45-N114)	≥95%
HY-P700047AF	Animal-Free ENA-78/CXCL5 Protein, Human (His)	P42830 (R45-N114)	≥95%

Related Diseases

Diseases

Alias

Pulmonary Sarcoidosis

Sarcoidosis, Pulmonary	Lung Sarcoidosis
Sarcoidosis Pulmonary	Lung Sarcoid
Sarcoidosis In Lung

Extrinsic Allergic Alveolitis

Hypersensitivity Pneumonitis	Alveolitis, Extrinsic Allergic
Alveolitis	Allergic Interstitial Pneumonitis
Allergic Pneumonitis	Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis
Hp	Pneumonitis Hypersensitivity
Allergic Alveolitis	Extrinsic Allergic Alveolitis Nos
Airway Obstruction With Allergic Alveolitis	Unspecified Allergic Alveolitis And Pneumonitis
Extrinsic Allergic Bronchiolo-Alveolitis	Hypersensitivity Pneumonia
Hypersensitivity Pneumonitis Nos	Obstructive Lung Disease With Allergic Alveolitis
Obstructive Lung Disorder With Hypersensitivity Pneumonitis	Obstructive Lung Disorder With Allergic Alveolitis
Obstructive Lung Disease With Hypersensitivity Pneumonitis

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Bacterial Meningitis

Meningitis, Bacterial	Meningitis Bacterial
Bm - [Bacterial Meningitis]	Leptomeningitis Bacterial
Pachymeningitis Bacterial	Arachnoiditis Bacterial

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Asymptomatic Neurosyphilis

Neurosyphilis

Neurosyphilis, Asymptomatic

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Chronic Congestive Splenomegaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120501	B022	Inhibitor	99.37%	Unkown
HY-163475	CXCL-CXCR1/2-IN-1	Inhibitor	99.64%	Unkown
HY-149393	RIPK3-IN-3	Inhibitor	/	Unkown
HY-RS03393	CXCL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CXCL5	MGD	MGI:1096868
Others	CXCL5	NCBI

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