2. Gene
  3. RNF123 - ring finger protein 123 Gene

RNF123 - ring finger protein 123 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KPC1; FP1477

Gene ID: 63891 | Gene type: protein coding

About RNF123

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,689,557-49,721,529 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 13.6), testis (RPKM 10.9) and 25 other tissues.

Summary

The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin Ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RNF123 Products(1)

mRNA Protein Name
NM_022064.5 NP_071347.2 E3 ubiquitin-protein ligase RNF123
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
15531880 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein maturation IDA
IDA: Inferred from direct assay
25860612 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
25860612 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15531880 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
15531880 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF123 Protein Structure

SPRY

SPRY: SPRY domain (132 - 253)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (1251 - 1298)

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  • 1314 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF123

Kip1 ubiquitination-promoting complex subunit 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12043 RNF123 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF123 RGD RGD:2301394
Macaca mulatta RNF123 VGNC VGNC:76790
Canis familiaris RNF123 VGNC VGNC:45626
Mus musculus RNF123 MGD MGI:2148796
Bos taurus RNF123 VGNC VGNC:34016