TNN - tenascin N Gene

Homo sapiens

Also known as TNW; TN-W

Gene ID: 63923 | Gene type: protein coding

About TNN

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:175,067,833-175,148,075 (from NCBI)

This gene has 2 transcripts (splice variants), 126 orthologues and 25 paralogues. Biased expression in fat (RPKM 11.1), thyroid (RPKM 1.5) and 2 other tissues.

Summary

Predicted to enable Integrin binding activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; and negative regulation of osteoblast differentiation. Predicted to act upstream of or within axonogenesis. Predicted to be located in extracellular matrix and neuron projection. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TNN Products(1)

mRNA	Protein	Name
NM_022093.2	NP_071376.1	tenascin-N precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of sprouting angiogenesis	IDA IDA: Inferred from direct assay	19884327	GOA
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	17909022	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	17909022	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	19884327	GOA
part of tenascin complex	IPI IPI: Inferred from physical interaction	17909022	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNN Protein Structure

fn3

Fibrinogen_C

0
200
400
600
800
1000
1200
1299 a.a.

Protein Preferred Names

Protein Names

tenascin-N

TN-N

Related Diseases

Diseases

Alias

Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN	Spondyloepiphyseal Dysplasia Nishimura Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14847	TNN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNN	RGD	RGD:1306002
Felis catus	TNN	VGNC	VGNC:66424
Mus musculus	TNN	MGD	MGI:2665790
Canis familiaris	TNN	VGNC	VGNC:47685
Bos taurus	TNN	VGNC	VGNC:36188
Macaca mulatta	TNN	VGNC	VGNC:79359
Others	TNN	NCBI

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