PRDM15 - PR/SET domain 15 Gene

Homo sapiens

Also known as PFM15; ZNF298; C21orf83

Gene ID: 63977 | Gene type: protein coding

About PRDM15

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,798,225-41,879,344 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues, 38 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 2.4), appendix (RPKM 1.2) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

PRDM15 Products(3)

mRNA	Protein	Name
NM_001040424.3	NP_001035514.2	PR domain zinc finger protein 15 isoform 2
NM_001282934.2	NP_001269863.2	PR domain zinc finger protein 15 isoform 3
NM_022115.7	NP_071398.5	PR domain zinc finger protein 15 isoform 1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15904895	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM15 Protein Structure

zf-C2H2

zf-C2H2_4

zf-C2H2

zf-C2H2_4

zf-C2H2

zf-H2C2_2

zf-C2H2

zf-C2H2_4

0
300
600
900
1200
1507 a.a.

Protein Preferred Names

Protein Names

PR domain zinc finger protein 15

PR domain 15

Related Diseases

Diseases

Alias

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11065	PRDM15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRDM15	VGNC	VGNC:102808
Bos taurus	PRDM15	VGNC	VGNC:33293
Rattus norvegicus	PRDM15	RGD	RGD:1310055
Mus musculus	PRDM15	MGD	MGI:1930121
Macaca mulatta	PRDM15	VGNC	VGNC:108429
Canis familiaris	PRDM15	VGNC	VGNC:44947

Name
Email *

	Sorry, but the email address you supplied was invalid.