SEMA3F - semaphorin 3F Gene

Homo sapiens

Also known as SEMA4; SEMAK; SEMA-IV

Gene ID: 6405 | Gene type: protein coding

About SEMA3F

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,155,058-50,189,075 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 19 paralogues. Broad expression in skin (RPKM 21.7), esophagus (RPKM 16.4) and 19 other tissues.

Summary

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce Apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

SEMA3F Products(3)

mRNA	Protein	Name
NM_001318798.2	NP_001305727.1	semaphorin-3F isoform 3
NM_001318800.2	NP_001305729.1	semaphorin-3F isoform 2 precursor
NM_004186.5	NP_004177.3	semaphorin-3F isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	15814794	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	15814794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA3F Protein Structure

Sema

0
200
400
600
785 a.a.

Protein Preferred Names

Protein Names

semaphorin-3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Recombinant SEMA3F Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71674	Semaphorin-3F/SEMA3F Protein, Human (HEK293, His)	Q13275 (S19-T785)	≥95%

Related Diseases

Diseases

Alias

Neuroma

Megacolon

Dilatation Of Colon

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Cone-Rod Dystrophy 10

CORD10

Dystrophy, Cone-Rod, Type 10

Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12655	SEMA3F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEMA3F	VGNC	VGNC:77164
Rattus norvegicus	SEMA3F	RGD	RGD:1308514
Canis familiaris	SEMA3F	VGNC	VGNC:45992
Mus musculus	SEMA3F	MGD	MGI:1096347
Bos taurus	SEMA3F	VGNC	VGNC:34431
Felis catus	SEMA3F	VGNC	VGNC:64990
Others	SEMA3F	NCBI

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