SEMG2 - semenogelin 2 Gene

Homo sapiens

Also known as SGII

Gene ID: 6407 | Gene type: protein coding

About SEMG2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,221,373-45,224,458 (from NCBI)

This gene has 1 transcript (splice variant), 39 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An Antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]

SEMG2 Products(1)

mRNA	Protein	Name
NM_003008.3	NP_002999.1	semenogelin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	8665956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8665956	GOA
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	15563730	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IMP IMP: Inferred from mutant phenotype	18714013	GOA
involved in coagulation	IDA IDA: Inferred from direct assay	8665956	GOA
involved in positive regulation of serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	15563730	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8665951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMG2 Protein Structure

Semenogelin

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

semenogelin-2

semenogelin II

Related Diseases

Diseases

Alias

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Atrial Septal Defect 9

ASD9	Atrial Heart Septal Defect 9
Septal Defect, Atrial, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12670	SEMG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEMG2	VGNC	VGNC:77173

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