C19orf33 - chromosome 19 open reading frame 33 Gene

Homo sapiens

Also known as IMUP; H2RSP; IMUP-1; IMUP-2

Gene ID: 64073 | Gene type: protein coding

About C19orf33

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,304,251-38,305,006 (from NCBI)

This gene has 4 transcripts (splice variants) and 46 orthologues. Biased expression in colon (RPKM 62.2), small intestine (RPKM 43.1) and 11 other tissues.

Summary

The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

C19orf33 Products(2)

mRNA	Protein	Name
NM_001317801.2	NP_001304730.1	immortalization up-regulated protein isoform IMUP-2
NM_033520.3	NP_277055.1	immortalization up-regulated protein isoform IMUP-1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	11080599	GOA
NOT enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	11080599	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11080599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

immortalization up-regulated protein

HAI-2 related small protein

Related Diseases

Diseases

Alias

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01704	C19orf33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C19orf33	RGD	RGD:2319167
Mus musculus	C19orf33	MGD	MGI:1919525

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