ACOT1 - acyl-CoA thioesterase 1 Gene

Homo sapiens

Also known as ACH2; CTE-1; LACH2

Gene ID: 641371 | Gene type: protein coding

About ACOT1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,490,933-73,543,796 (from NCBI)

This gene has 2 transcripts (splice variants), 436 orthologues and 4 paralogues. Broad expression in fat (RPKM 27.2), liver (RPKM 24.9) and 24 other tissues.

Summary

Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ACOT1 Products(1)

mRNA	Protein	Name
NM_001037161.2	NP_001032238.1	acyl-coenzyme A thioesterase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	16940157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	16940157	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	16940157	GOA
involved in very long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	16940157	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	16940157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT1 Protein Structure

Bile_Hydr_Trans

BAAT_C

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A thioesterase 1

CTE-I

Related Diseases

Diseases

Alias

Aztreonam Allergy

Azactam Allergy

Primbactam Allergy

Cefaclor Allergy

Ceclor Allergy

Cephaclor Allergy

Cefuroxime Allergy

Cephuroxime Allergy

Zinacef Allergy

Ceftriaxone Allergy

Rocephin Allergy

Anorectal Stricture

Stenosis Of Rectum And Anus

Anorectal Malformations

Mitochondrial Pyruvate Carrier Deficiency

MPYCD

Pitt-Hopkins-Like Syndrome 2

PTHSL2	Mesh
D006985	Mesh
D008607

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00173	ACOT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACOT1	RGD	RGD:70894
Mus musculus	ACOT1	MGD	MGI:1349396

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