1. Gene
  2. SELENOP - selenoprotein P Gene

SELENOP - selenoprotein P Gene

Homo sapiens

Also known as SeP; SELP; SEPP; SEPP1

Gene ID: 6414 | Gene type: protein coding

About SELENOP

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:42,799,880-42,811,892 (from NCBI)

This gene has 15 transcripts (splice variants) and 177 orthologues. Broad expression in liver (RPKM 1192.8), small intestine (RPKM 1057.6) and 22 other tissues.

Summary

This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via Apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]

SELENOP Products(3)

mRNA Protein Name
NM_001085486.3 NP_001078955.1 selenoprotein P isoform 1 precursor
NM_001093726.3 NP_001087195.1 selenoprotein P isoform 2
NM_005410.4 NP_005401.3 selenoprotein P isoform 1 precursor

SELENOP Protein Structure

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_N

SelP_N: Selenoprotein P, N terminal region (22 - 250)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

SelP_C

SelP_C: Selenoprotein P, C terminal region (251 - 381)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
Protein Preferred Names Protein Names

selenoprotein P

selenoprotein P, plasma, 1

Related Diseases

Diseases Alias
Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diabetes Mellitus

Diabetes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SELENOP MGD MGI:894288
Rattus norvegicus SELENOP RGD RGD:3660
Bos taurus SELENOP VGNC VGNC:109401
Others SELENOP NCBI