SFRP2 - secreted frizzled related protein 2 Gene

Homo sapiens

Also known as FRP-2; SARP1; SDF-5

Gene ID: 6423 | Gene type: protein coding

About SFRP2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:153,780,591-153,789,083 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 15 paralogues. Biased expression in urinary bladder (RPKM 276.9), gall bladder (RPKM 211.4) and 9 other tissues.

Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal Cancer. [provided by RefSeq, Jul 2008]

SFRP2 Products(1)

mRNA	Protein	Name
NM_003013.3	NP_003004.1	secreted frizzled-related protein 2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	19593212	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19095296	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	20208569	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17471511	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	20208569	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	20208569	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17848950	GOA
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	19095296	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	19095296	GOA
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19593212	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17848950	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10980594	GOA
acts upstream of or within positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	12055200	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10980594	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFRP2 Protein Structure

NTR

0
100
200
295 a.a.

Protein Preferred Names

Protein Names

secreted frizzled-related protein 2

SARP-1

Recombinant SFRP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77835	SFRP2 Protein, Human (HEK293, His, solution)	Q96HF1 (L25-C295)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Esophageal Basaloid Squamous Cell Carcinoma

Basaloid Squamous Carcinoma Of Esophagus

Esophageal Basaloid Carcinoma

Retinal Degeneration

Degeneration Of Retina

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12775	SFRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SFRP2	VGNC	VGNC:77186
Mus musculus	SFRP2	MGD	MGI:108078
Felis catus	SFRP2	VGNC	VGNC:107462
Bos taurus	SFRP2	VGNC	VGNC:34521
Rattus norvegicus	SFRP2	RGD	RGD:735163
Canis familiaris	SFRP2	VGNC	VGNC:46081
Macaca fascicularis	SFRP2	NCBI	NCBI:102147309
Others	SFRP2	NCBI

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