RAB17 - RAB17, member RAS oncogene family Gene

Homo sapiens

Gene ID: 64284 | Gene type: protein coding

About RAB17

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,574,326-237,590,734 (from NCBI)

This gene has 11 transcripts (splice variants), 147 orthologues and 68 paralogues. Biased expression in duodenum (RPKM 20.0), small intestine (RPKM 19.8) and 12 other tissues.

Summary

The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

RAB17 Products(1)

mRNA	Protein	Name
NM_022449.4	NP_071894.1	ras-related protein Rab-17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	17646400	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17646400	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endocytic vesicle	IDA IDA: Inferred from direct assay	17646400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB17 Protein Structure

Ras

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-17

RAB17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB17	Q9H0T7	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	RAB17	Q9H0T7	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	RAB17	Q9H0T7	CSTPP1	Homo sapiens	Q9H6J7	Y2H Prey Pooling	25416956
Intra	RAB17	Q9H0T7	CSTPP1	Homo sapiens	Q9H6J7	Validated Y2H	25416956
Intra	RAB17	Q9H0T7	MAGEA1	Homo sapiens	P43355	Validated Y2H	25416956
Intra	RAB17	Q9H0T7	MAGEA1	Homo sapiens	P43355	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11525	RAB17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB17	VGNC	VGNC:81520
Mus musculus	RAB17	MGD	MGI:104640
Rattus norvegicus	RAB17	RGD	RGD:1562478
Felis catus	RAB17	VGNC	VGNC:80333
Bos taurus	RAB17	VGNC	VGNC:59174
Canis familiaris	RAB17	VGNC	VGNC:45256

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